Spermicidal, Antifertility and Contraceptive Effect of Azadirachta indica A. Juss. Seed Extract in Female and Male Wistar Rats

This study investigates the spermicidal and contraceptive effect of Azadirachta indica seed aqueous extract in male female Wistar rats. The animals were divided into four groups (n=6), graded doses (2.5, 5, 10 mg/kg) extract. They exposed to rats a ratio 2:1 after 24 hours, 7, 14 days administration. properties evaluated. involved pre-coital post-coital administration neem extract, indexes investigated. results obtained from activity showed significant decrease hormonal levels at 2.5, mg/kg A. (0.73, 0.50, 1.08 ng/ml); sperm cells (102.5, 111.5, 97 counts) hours. Administration mating, compared control. Also, histopathology testes normal testicles. elicited estrogen (1.46 ng/ml), luteinizing hormone (0.094 mg/dl) µand progesterone (1.82 5 day with treated uterus had no deteriorating potential reduced dose, validating its folklore claim.